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Eliquis (Apixaban) is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation. Eliquis (Apixaban) is also used after hip or knee replacement surgery to prevent a type of blood clot called deep vein thrombosis (DVT), which can cause blood clots in the lungs (pulmonary embolism). Apixaban is also used to treat DVT or pulmonary embolism (PE), and to lower the risk of having a repeat DVT or PE.